DID THE MONKEYPOX (MPXV22) OUTBREAK COME FROM A LAB?
location, transmissibility, number and type of mutations strongly suggest sohttps://abs.twimg.com/emoji/v2/... draggable="false" alt="😬" title="Grijnzend gezicht" aria-label="Emoji: Grijnzend gezicht">

disclaimer: this is a PRELIMINARY analysis, a first look, an invitation to an open discussion,https://abs.twimg.com/emoji/v2/... draggable="false" alt="🙏" title="Gevouwen handen" aria-label="Emoji: Gevouwen handen">rt!
I hope to be wrong.
But the data...https://abs.twimg.com/emoji/v2/... draggable="false" alt="😱" title="Gezicht dat schreeuwt van angst" aria-label="Emoji: Gezicht dat schreeuwt van angst">
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1/x

Disclaimer 2:
Please leave all your
-ad hominem/you& #39;re not a virologist
-monkeypox is harmless
-but some expert said something else
-you& #39;re a conspiracy theorist
-first prove it 100%
arguments at home.
Point out
-analytical mistakes
-opposing data
-better explanations
please!
2/x

Let& #39;s get to the facts:

1) LOCATION
The case numbers suggest that the MPXV22 outbreak started in Europe, likely in the London area: There was one patient who travelled from Nigeria, but he was isolated and his contacts traced.
All others outbreaks started in Africa.
3/x

2) TRANSMISSIBILITY
MPXV22 rapid spread is highly unusual.
Increased transmissibility can be explained by prolonged spreading among humans (which wasn& #39;t observed, neither were intermediate strains) or e.g. lab experiments such as passaging with human cells.
4/x

3) NUMBER OF MUTATIONS
DNA viruses usually mutate very slowly, accumulating 1-2 mutations/year. This MPXV22 mutated 6-12x faster, which AFAIK has never before been observed in nature.
(sources of many following statements:
https://virological.org/t/discussion-of-on-going-mpxv-genome-sequencing/802
https://virological.org/t/discuss... href=" https://www.researchsquare.com/article/rs-1700947/v1)
5/x">https://www.researchsquare.com/article/r...

https://www.researchsquare.com/article/r..." title="3) NUMBER OF MUTATIONSDNA viruses usually mutate very slowly, accumulating 1-2 mutations/year. This MPXV22 mutated 6-12x faster, which AFAIK has never before been observed in nature.(sources of many following statements: https://virological.org/t/discuss... href=" https://www.researchsquare.com/article/rs-1700947/v1)5/x">https://www.researchsquare.com/article/r...">

https://www.researchsquare.com/article/r..." title="3) NUMBER OF MUTATIONSDNA viruses usually mutate very slowly, accumulating 1-2 mutations/year. This MPXV22 mutated 6-12x faster, which AFAIK has never before been observed in nature.(sources of many following statements: https://virological.org/t/discuss... href=" https://www.researchsquare.com/article/rs-1700947/v1)5/x">https://www.researchsquare.com/article/r...">